Gene responsible for brain tumour radiation resistance identified

American molecular biologists have found that high activity of the ZMYND8 gene protects many forms of glioma – malignant brain tumours – from being destroyed by radiotherapy. Suppression of this gene made the culture of tumour bodies vulnerable to radiation – as reported in the press service of the University of Michigan, TASS reports

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University Professor Pedro R. Lowenstein noted that increased activity of the ZMYND8 gene protects glioma cells with a mutation in the IDH1 gene from the effects of radiation. “Our experiments have shown that the suppression of this DNA area with the help of mRNA therapy makes tumour bodies vulnerable to the action of ionising radiation,” he said.